Cluedo, known as Clue in North America, is a murder mystery-themed multimedia franchise started in 1949 with the manufacture of the Cluedo board game. The franchise has since expanded to film, television gameshows, book series, computer games, board game spinoffs, a comic, a play, a musical, jigsaws, card games, and other media.

Waddingtons, Parker Brothers, and Hasbro have created many spin-off versions of the game, consisting of alternative rules varying from the original Classic Detective Game. (Such spin-offs are distinct from themed "variants" using the basic rules and game configuration, effectively new skins on the original board game.) In addition to revising the rules of gameplay, many of the spin-off games also introduce new characters, locations, weapons, and/or alternative objectives.